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By reducing overall caloric intake through appetite suppression and early satiety, these agents create an energy deficit that mobilizes stored fat

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Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, et al

Delayed gastric emptying was the most common problem (80% of patients), while 33% had slower small bowel and colon transit [29]